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. Author manuscript; available in PMC: 2014 Jan 20.
Published in final edited form as: Biochim Biophys Acta. 2011 Aug 3;1819(0):322–331. doi: 10.1016/j.bbagrm.2011.07.014

Figure 2. Structure function of SAHF.

Figure 2

Normal proliferating cells have diffuse DAPI staining associated with euchromatin. Senescent cells form punctate foci termed SAHF, which are heterochromatic based on markers such as HP1 proteins, H3K9Me3 and hypoacetylated histones. On the one hand, SAHF might contribute to tumor suppression via repression of proliferating promoting genes such as cyclin A. On the other hand, SAHF may dampen the DNA damage response, suppress apoptosis and promote viability of senescent cells.