Table S2.
Differences in functional connectivity between groups within the fronto-parietal network and the thalamus.
| ROI | ROI | HC vs. MCS | HC vs. VS/UWS | MCS vs. VS/UWS |
|---|---|---|---|---|
| Medial frontal to medial parietal | ||||
| Right Frontal Pole | Right Posterior Cingulate Cortex | HC > VS/UWS | ||
| Left Medial Frontal Cortex | Left Posterior Cingulate Cortex | HC > MCS | HC > VS/UWS | |
| Left Medial Frontal Cortex | Right Posterior Cingulate Cortex | HC > MCS | HC > VS/UWS | |
| Right Medial Frontal Cortex | Left Posterior Cingulate Cortex | HC > MCS | HC > VS/UWS | |
| Right Medial Frontal Cortex | Right Posterior Cingulate Cortex | HC > VS/UWS | ||
| Left Medial Frontal Cortex | Left Precuneus | HC > MCS | ||
| Left Medial Frontal Cortex | Right Precuneus | HC > MCS | ||
| Right Medial Frontal Cortex | Left Precuneus | HC > MCS | HC > VS/UWS | |
| Left Anterior Cingulate Cortex | Left Posterior Cingulate Cortex | HC > MCS | HC > VS/UWS | |
| Left Anterior Cingulate Cortex | Right Posterior Cingulate Cortex | HC > MCS | HC > VS/UWS | |
| Right Anterior Cingulate Cortex | Left Posterior Cingulate Cortex | HC > MCS | HC > VS/UWS | |
| Right Anterior Cingulate Cortex | Right Posterior Cingulate Cortex | HC > MCS | HC > VS/UWS | |
| Left Anterior Cingulate Cortex | Left Precuneus | HC > MCS | ||
| Left Anterior Cingulate Cortex | Right Precuneus | HC > MCS | ||
| Right Anterior Cingulate Cortex | Right Precuneus | HC > MCS | ||
| Left Supplementary Motor Areal | Left Posterior Cingulate Cortex | HC > VS/UWS | ||
| Left Supplementary Motor Areal | Left Precuneus | HC > VS/UWS | ||
| Right Supplementary Motor Areal | Left Precuneus | HC > MCS | HC > VS/UWS | |
| Right Supplementary Motor Areal | Right Precuneus | HC > MCS | ||
| Within medial frontal | ||||
| Left Frontal Pole | Right Orbital Frontal Cortex | HC < MCS | ||
| Right Frontal Pole | Right Orbital Frontal Cortex | HC < MCS | HC < VS/UWS | |
| Right Frontal Pole | Right Anterior Cingulate Cortex | HC > VS/UWS | ||
| Left Medial Frontal | Left Supplementary Motor Areal | HC > MCS | ||
| Right Medial Frontal | Left Supplementary Motor Areal | HC > MCS | ||
| Right Medial Frontal | Right Supplementary Motor Areal | HC > MCS | ||
| Left Orbital Frontal Cortex | Right Orbital Frontal Cortex | HC > MCS | ||
| Right Orbital Frontal Cortex | Left Anterior Cingulate Cortex | HC > MCS | HC > VS/UWS | |
| Right Orbital Frontal Cortex | Right Anterior Cingulate Cortex | HC > MCS | HC > VS/UWS | |
| Medial frontal to left frontal | ||||
| Left Frontal Pole | Left Superior Frontal Gyrus | HC > VS/UWS | MCS > VS/UWS | |
| Left Frontal Pole | Left Middle Frontal Gyrus | HC > VS/UWS | ||
| Right Medial Frontal Cortex | Left Frontal Operculum | HC < VS/UWS | ||
| Left Orbital Frontal Cortex | Right Inferior Frontal Gyrus, pars triangularis | HC > MCS | HC > VS/UWS | |
| Left Anterior Cingulate Cortex | Left Inferior Frontal Gyrus, pars opercularis | HC < MCS | ||
| Right Anterior Cingulate Cortex | Left Inferior Frontal Gyrus, pars opercularis | HC < MCS | ||
| Right Supplementary Motor Areal | Left Middle Frontal Gyrus | HC < MCS | ||
| Medial frontal to right frontal | ||||
| Right Frontal Pole | Right Superior Frontal Gyrus | HC > VS/UWS | MCS > VS/UWS | |
| Right Frontal Pole | Right Middle Frontal Gyrus | HC > MCS | HC > VS/UWS | |
| Right Orbital Frontal Cortex | Right Middle Frontal Gyrus | HC > VS/UWS | ||
| Right Orbital Frontal Cortex | Right Inferior Frontal Gyrus, pars triangularis | HC > MCS | ||
| Left Anterior Cingulate Cortex | Right Inferior Frontal Gyrus, pars triangularis | HC > MCS | HC > VS/UWS | |
| Left Anterior Cingulate Cortex | Right Frontal Operculum | HC > MCS | HC > VS/UWS | |
| Left Supplementary Motor Areal | Right Frontal Operculum | HC > MCS | HC > VS/UWS | |
| Right Supplementary Motor Areal | Right Frontal Operculum | HC > MCS | HC > VS/UWS | |
| Medial frontal to temporo-parietal junction | ||||
| Left Frontal Pole | Left Angular Gyrus | HC > VS/UWS | ||
| Right Frontal Pole | Right Angular Gyrus | HC > MCS | HC > VS/UWS | |
| Left Anterior Cingulate Cortex | Left Angular Gyrus | HC > VS/UWS | ||
| Left Anterior Cingulate Cortex | Right Angular Gyrus | HC > MCS | HC > VS/UWS | |
| Right Anterior Cingulate Cortex | Right Angular Gyrus | HC > MCS | HC > VS/UWS | |
| Medial frontal to thalamus | ||||
| Left frontal Pole | Right Thalamus | HC > VS/UWS | ||
| Right frontal Pole | Right Thalamus | HC > VS/UWS | ||
| Left Medial Frontal Cortex | Right Thalamus | HC > MCS | HC > VS/UWS | |
| Right Medial Frontal Cortex | Left Thalamus | HC > MCS | HC > VS/UWS | |
| Right Medial Frontal Cortex | Right Thalamus | HC > MCS | ||
| Left Orbital Frontal Cortex | Left Thalamus | HC > MCS | ||
| Right Orbital Frontal Cortex | Left Thalamus | HC > MCS | HC > VS/UWS | |
| Right Orbital Frontal Cortex | Right Thalamus | HC > VS/UWS | ||
| Medial frontal to insular | ||||
| Left Anterior Cingulate Cortex | Right Insular Cortex | HC > MCS | ||
| Right Anterior Cingulate Cortex | Right Insular Cortex | HC > MCS | ||
| Left Supplementary Motor Areal | Left Insular Cortex | HC > MCS | HC > VS/UWS | |
| Left Supplementary Motor Areal | Right Insular Cortex | HC > MCS | HC > VS/UWS | |
| Right Supplementary Motor Areal | Left Insular Cortex | HC > MCS | HC > VS/UWS | |
| Right Supplementary Motor Areal | Right Insular Cortex | HC > MCS | HC > VS/UWS | |
| Within medial posterior | ||||
| Left Posterior Cingulate Cortex | Left Precuneus | HC > VS/UWS | ||
| Left Posterior Cingulate Cortex | Right Precuneus | HC > MCS | ||
| Right Posterior Cingulate Cortex | Left Precuneus | HC > MCS | HC > VS/UWS | |
| Right Posterior Cingulate Cortex | Right Precuneus | HC > MCS | HC > VS/UWS | |
| Left Posterior Cingulate Cortex | Right Posterior Cingulate Cortex | HC > MCS | HC > VS/UWS | |
| Left Precuneus | Right Precuneus | HC > MCS | ||
| Medial posterior to left frontal | ||||
| Right Posterior Cingulate Cortex | Left Inferior Frontal Gyrus, pars triangularis | HC < MCS | ||
| Right Posterior Cingulate Cortex | Left Inferior Frontal Gyrus, pars opercularis | HC < MCS | ||
| Left Precuneus | Left Inferior Frontal Gyrus, pars triangularis | HC < MCS | ||
| Right Precuneus | Left Inferior Frontal Gyrus, pars triangularis | HC < MCS | HC < VS/UWS | |
| Left Precuneus | Left Inferior Frontal Gyrus, pars opercularis | HC < MCS | ||
| Right Precuneus | Left Inferior Frontal Gyrus, pars opercularis | HC < MCS | HC < VS/UWS | |
| Medial posterior to temporo-parietal junction | ||||
| Left Posterior Cingulate Cortex | Left Angular Gyrus | HC > VS/UWS | ||
| Left Posterior Cingulate Cortex | Right Angular Gyrus | HC > MCS | ||
| Right Posterior Cingulate Cortex | Right Angular Gyrus | HC > VS/UWS | ||
| Medial posterior to thalamus | ||||
| Left Posterior Cingulate Cortex | Right Thalamus | HC > MCS | HC > VS/UWS | |
| Right Posterior Cingulate Cortex | Left Thalamus | HC > VS/UWS | ||
| Left Precuneus | Left Thalamus | HC > MCS | HC > VS/UWS | |
| Left Precuneus | Right Thalamus | HC > MCS | HC > VS/UWS | |
| Right Precuneus | Left Thalamus | HC > VS/UWS | ||
| Right Precuneus | Right Thalamus | HC > MCS | HC > VS/UWS | |
| Between lateral frontal | ||||
| Left Inferior Frontal Gyrus, pars triangularis | Right Inferior Frontal Gyrus, pars triangularis | HC > MCS | HC > VS/UWS | |
| Left Inferior Frontal Gyrus, pars triangularis | Right Inferior Frontal Gyrus, pars opercularis | HC > VS/UWS | ||
| Left Inferior Frontal Gyrus, pars opercularis | Right Inferior Frontal Gyrus, pars triangularis | HC > MCS | HC > VS/UWS | |
| Left Inferior Frontal Gyrus, pars opercularis | Right Inferior Frontal Gyrus, pars opercularis | HC > MCS | ||
| Left frontal to temporo-parietal junction | ||||
| Left Superior Frontal Gyrus | Left Angular Gyrus | HC > VS/UWS | ||
| Left Middle Frontal Gyrus | Left Angular Gyrus | HC > VS/UWS | ||
| Within right frontal | ||||
| Right Superior Frontal Gyrus | Right Inferior Frontal Gyrus, pars triangularis | HC > VS/UWS | ||
| Right frontal to temporo-parietal junction | ||||
| Right Superior Frontal Gyrus | Right Angular Gyrus | HC > VS/UWS | ||
| Right Middle Frontal Gyrus | Right Angular Gyrus | HC > MCS | HC > VS/UWS | |
| Right frontal to insular | ||||
| Right Middle Frontal Gyrus | Left Insular Cortex | HC > VS/UWS | ||
| Right Frontal Operculum | Left Insular Cortex | HC > MCS | HC > VS/UWS | |
| Right Frontal Operculum | Right Insular Cortex | HC > VS/UWS | ||
| Left temporo-parietal junction to right temporo-parietal junction | ||||
| Left Angular Gyrus | Right Angular Gyrus | HC > MCS | HC > VS/UWS | |
| Within thalamus | ||||
| Left Thalamus | Right Thalamus | HC > MCS | ||
| Within insular | ||||
| Left Insular Cortex | Right Insular Cortex | HC > MCS | HC > VS/UWS | |
p < .05 corrected for multiple comparisons; HC = healthy control group; MCS = minimally conscious state; UWS = unresponsive wakefulness syndrome.