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. 2013 Dec 11;4:209–231. doi: 10.1016/j.nicl.2013.11.009

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© 2013 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig. 1 — The extended medial prefrontal network of youth MDD. Shown are brain regions most consistently implicated in fMRI studies of adolescent and youth MDD across 5 domains of functioning. The center panel shows the ‘hub’ of the extended medial network, comprising the anterior cingulate (pregenual, mid-cingulate and subgenual cingulate cortices) and posterior cingulate cortices, and ventromedial prefrontal cortex encompassing medial portions of BA 10 and caudal portions of orbitofrontal cortex/BA 11. Left panel: Cortical regions of the extended medial prefrontal network showing dorsolateral prefrontal cortex (top) and the medial and lateral portions of the orbitofrontal cortex (bottom). Right panel: Coronal slices showing subcortical regions including the amygdala (top) and striatum (bottom). The coronal slice of the striatum (MNI coordinate y = 12 mm) shows the dorsal caudate, and the dorsal and ventral divisions of the putamen.