Table 2. PRG4 gene mutations identified.
Patientsa | Location | Mutation at cDNA level | Deduced mutation at protein level |
---|---|---|---|
1 | Exon 6 | c.2754_2758delGACAA | p.Lys918Asnfs*10 |
2 | Intron 8 | c.3636+3A>G | p.Hys1168Phefs*9 |
3, 11 and 12 | Exon 10 | c.3894_3898delGGTTA | p.Val1299Glufs*5 |
4 | Exon 6 | c.1982_1983delCT | p.Pro661Argfs*17 |
5 and 6 | Exon 9 | c.3648C>A | p.Tyr1216* |
10 | Exon 6 | c.2153delA | p.Lys718Argfs*194 |
The identification number of the patients is the one stated in Table 1. *indicate a translation termination codon.