Table 1.
Summary of available tocotrienol formulations including source, delivery systems, excipients and composition of tocorienol homologues
Tocotrienol formulations | Source | Dosage form | Delivery system | Excipients and vehicles | Composition of tocotrienol homologues (% w/w) * | Reference |
---|---|---|---|---|---|---|
Palm Vitee |
Palm |
Capsule |
Oil suspension |
Palm olein |
α: 12-15%, γ: 35-40%, δ: 25-30% |
[37,38,42,45-47] |
Tocovid Suprabio® |
Palm |
Capsule |
Self-emulsifying drug delivery system |
Tween 80, Labrasol, Palm olein/Soybean oil |
α: 23.5%, γ: 43.2%, δ: 9.8% |
[22,26,28,40,44,48] |
Tocomin® 50% |
Palm |
Emulsion |
Self-emulsifying drug delivery system |
Tween 80, Labrasol, Soybean Oil |
α: 10.7%, γ: 21.6%, δ: 6.4% |
[32] |
Tri® E |
Palm |
Capsule |
Oil suspension |
Palm superolein |
74% of mixed homologues** |
[49-51] |
Tocotrienol-rich fractions (TRF) |
Palm |
Capsule |
Oil suspension |
Vegetable oils |
α: 34.6%, γ: 24.6%, δ: 15.0%, |
[39] |
α: 29.3%, β: 3.0%, γ: 28.1%, δ: 8.2% |
[21] |
|||||
α: 29..8%, β: 2.9%, γ: 27.0%, δ: 8.6% |
[23] |
|||||
66.7% of mixed homologues** |
[43] |
|||||
Rice Bran |
Capsule |
Oil suspension |
Vegetable oils |
α: 14.6%, β: 2.2%, γ: 38.8%, δ: 29.9% |
[36] |
|
TRF25 containing α: 15.5%, β: 1.6%, γ: 39.4%, δ: 5.2%, desmethyl and didesmethyl: 20.9% |
[41,52,53] |
|||||
Various compositionally different tocotrienols supplements |
[54] |
|||||
Individual tocotrienol homologues | Palm | Capsule | Oil suspension | Olive oil |
30 mg of γδ-tocotrienols** |
[55] |
Medium-chain triglyceride | α, γ and δ-tocotrienyl acetate | [56] |
*% w/w of tocotrienol homologues calculated based on g / 100 g of total vitamin E content.
**Composition of individual tocotrienol homologue not specified.