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. 2014 Jan 9;10:2. doi: 10.1186/1744-8069-10-2

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Copyright © 2014 Kwon et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The effect of AMG9810 and chelerythrine on established thermal hyperalgesia (TH) in acidic saline injected TIIP (AS-TIIP) rats. Effects of AMG9810 (a TRPV1 antagonist) and chelerythrine (a PKC inhibitor) in established TH were evaluated at day 3 post-surgery and pH 4.0 injection. (A) Intraplantar injection of AMG9810 (3 and 10 nmol) was effective in reversing the established TH in a dose dependent manner (n = 4, 4, 5 in each group). The analgesic effect of AMG9810 was significant at 30 min and 1 h post-injection (*p < 0.05, **p < 0.01 and ***p < 0.001 vs vehicle). (B) Intraplantar injection of chelerythrine (10 and 30 nmol) dose dependently reversed TH at the 1 and 3 h time point after injection in established TH rats (n = 4, 6, 6 in each group, ***p < 0.001 vs vehicle).