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Clock genes and hypertension. Fifteen-day mean arterial blood pressure recorded under high-salt diet conditions. Mice lacking the core clock components Cryptochrome1 (Cry1) and Cryptochrome2 (Cry2) (Cry1−/− Cry2−/−, upper panel) show salt-sensitive hypertension, while the wild type (WT) doesn't. This hypertension can be avoided with the aldosterone inhibitor, Eplerenone. The figures are adapted from Macmillan Publishers Ltd: Nature Medicine, Doi et al. (2010), copyright 2010.
