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. 2014 Jan 2;6(1):1. doi: 10.1186/1868-7083-6-1

Table 1.

Top pathways and associated networks identified by pathway analysis for the hippocampus following olanzapine treatment

(a) Top canonical pathways (Genes with increased methylation) P- value No of molecules a
Dopamine-DARPP32 feedback in cAMP signalling
1.65 × 10–3
20/157 (0.127)
CD27 signalling in lymphocytes
2.42 × 10–4
11/54 (0.204)
Oestrogen-mediated S-phase entry
2.56 × 10–3
6/26 (0.231)
Role of JAK2 in hormone-like cytokine signalling
3.38 × 10–3
7/34 (0.206)
Associated network functions
 
 
Metabolic disease, endocrine system and developmental disorders
35
Cell cycle, cellular growth and proliferation, cell death
24
Molecular transport, neurological disease, cell-to-cell signalling
10
(b) Top canonical pathways (Genes with decreased methylation)
P- value
No of molecules
CDC42 signalling
2.52 × 10–3
11/131 (0.084)
Prostanoid biosynthesis
2.55 × 10–3
3/9 (0.333)
Calcium signalling
5.92 × 10–3
12/178 (0.067)
D-myo-inositol (1,3,4,5,6)-tetrakisphosphatebiosynthesis
6.18 × 10–3
8/48 (0.167)
Associated network functions
 
Developmental disorder, cell death and survival, cellular development
12
Molecular transport, nervous system development and function
10
Carbohydrate metabolism, cell morphology, lipid metabolism
9
Cellular development, skeletal, muscular and cardiovascular system development and function 8

aFor the top canonical pathways, the ratio is the number of molecules in a given pathway that meet the cut-off (P ≤ 0.01) divided by the total number of molecules in the pathway.