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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Cancer Immunol Res. 2013 Aug;1:99–111. doi: 10.1158/2326-6066.CIR-13-0047

Figure 3.

Figure 3

Fine specificity mapping of TRP TN TCR specificities. A) An altered peptide library (as shown) was generated by substitution of non MHC contact residues. B) CD8 T cells isolated from TRP1high or TRP1low mice were cocultured with BMDCs pulsed with the indicated peptides at 100 ng/mL. IL-2 was measured by ELISA of 24hr culture supernatants. IFN-γ was measured by ELISA of 72hr culture supernatants. Representative of 2 independent experiments. Error bars are SD of triplicate samples.