Table 1. Cloning of the Ganglioside Synthase Genes.
| Glycosyltransferases | Other names in ganglioside biosynthesis | Products | GenBank accession number (References)* |
|---|---|---|---|
| ST3Gal I (EC 2.4.99.4) | GM1b/GD1a/GT1b/GQ1c-synthase, ST-IV | GM1b, GD1a, GT1b, GQ1c | Mmu X73523 (10); Has L29555 (11) |
| ST3Gal V (EC 2.4.99.9) | GM3-synthase, ST-I | GM3 | Has AB018356 (12); Mmu Y15003 (13); Rno AB018049 |
| ST8Sia I (EC 2.4.99.8) | GD3-synthase, ST-II | GD3 (GD1c, GT1a, GQ1b, GT3?) | Has D26360 (15) Mmu X84235; Rno U53883 (19) |
| ST8Sia V | GD1c/GT1a/GQ1b/GQ1c-synthase, ST-V | GD1c, GT1a, GQ1b, GP1c, (GT3?) | Mmu X98014 (24); Has U91641 (25) |
| ST6GalNAc III (EC 2.4.99.7) | GD1α, GM1b | Rno L29554 (29); Y11342 (30) | |
| ST6GalNAc VI | GD1α, GM1b | Mmu AB030836 (31) | |
| UDP-Gal β1,4Gal T | LacCer-synthase, Gal T-I | LacCer | Rno AF048687 (39); Has AF097159 (40) |
| UDP-Gal β1,3Gal T | GA1/GM1/GD1b/GT1c-synthses, Gal T-II | GA1, GM1, GD1b, GT1c | Rno AB003478 (42); Has Y15061 (43); Mmu AF082504 (44) |
| Ceramide UDP-Gal T (EC 2.4.1.45) | GalCer-synthase, Gal T-III | GalCer | Rno L21698 (47); Mmu X92122 (48); Has U62899 (50) |
| β1,4GalNAc T (EC 2.4.1.92) | GA2/GM2/GD2/GT2-synthase, GalNAc T | GA2, GM2, GD2, GT2 | Has M83651 (58); Rno D17809 (59); Mmu L25885 (60) |
| β1,1Glc-T (EC 2.4.1.80) | GlcCer-synthase, Glc T | GlcCer | Has D50840 (66); Mmu D89866 (67); Rno AF047707 (68) |
*
Sequences obtained by homolog search of the available databases are not present. Mmu, Mus musculus; Rno, Rattus norvegicus; Hsa, Homo sapiens.