. 2013 Jul 24;15(12):1319–1326. doi: 10.1093/eurjhf/hft118

Table 1.

Haemodynamic, ventriculographic, echocardiographic, and Doppler measures in canines randomized to the 6-month longitudinal study

Measurement	Arm	Baseline	PRE	3 months	6 months
HR (b.p.m.)	Control	81 ± 3	78 ± 2	83 ± 2	86 ± 3
HR (b.p.m.)	VNS	83 ± 3	81 ± 2	82 ± 3	85 ± 3
mAoP (mmHg)	Control	74 ± 5	68 ± 3	73 ± 2	74 ± 1
mAoP (mmHg)	VNS	78 ± 2	72 ± 3	72 ± 3	80 ± 4
LVEDP (mmHg)	Control	10 ± 0.5	12 ± 0.8	14 ± 1.0	14 ± 1.1
LVEDP (mmHg)	VNS	10 ± 0.5	14 ± 0.9	12 ± 0.8*	12 ± 0.5
SV (mL)^a	Control	27 ± 1.5	19 ± 0.9	19 ± 0.9	19 ± 0.9
SV (mL)^a	VNS	26 ± 0.9	19 ± 0.7	21 ± 0.7*	23 ± 1.1^†
CO (L/min)^a	Control	2.20 ± 0.17	1.51 ± 0.07	1.56 ± 0.08	1.58 ± 0.03
CO (L/min)^a	VNS	2.17 ± 0.13	1.55 ± 0.07	1.76 ± 0.11*	1.99 ± 0.10^†
PE/PA	Control	3.3 ± 0.1	2.2 ± 0.2	2.0 ± 0.1	2.0 ± 0.1
PE/PA	VNS	3.2 ± 0.1	2.0 ± 0.1	2.3 ± 0.1*	2.2 ± 0.1
DT (ms)	Control	110 ± 3	80 ± 4	78 ± 5	72 ± 5
DT (ms)	VNS	114 ± 2	76 ± 3	83 ± 5*	88 ± 5^†
EDWS (gm/cm²)	Control	32 ± 3	51 ± 4	62 ± 6	60 ± 7
EDWS (gm/cm²)	VNS	37 ± 3	68 ± 8	59 ± 7*	56 ± 4^†

Values are given as the mean ± SEM.

CO, cardiac output; DT, deceleration time of early mitral inflow velocity; EDP, LV end-diastolic pressure; EDWS, end-diastolic circumferential wall stress; HR, heart rate; mAoP, mean aortic pressure; PE/PA, ratio of peak mitral inflow velocity in early diastole (PE) to peak mitral inflow velocity during left atrial contraction (PA); SV, stroke volume; VNS, vagus nerve stimulation.

^aVentriculography-derived data.

*P < 0.05 VNS vs. control Δ from PRE to 3 months; †P < 0.05 VNS vs. control Δ from 3 to 6 months.