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. 1971 Dec;68(12):3130–3135. doi: 10.1073/pnas.68.12.3130

Autoimmune-Like Antibodies to the Ligand-Binding Sites of Myeloma Proteins

Stitaya Sirisinha 1,*, Herman N Eisen 1,†
PMCID: PMC389606  PMID: 4108872

Abstract

BALB/c mice were immunized with three A-myeloma proteins of BALB/c-2 or BALB/c origin (produced by plasmacytomas MOPC-315, MOPC-460, Adj. PC-22A). Noncross reacting antibodies were formed against Proteins-315 and 460, but the response to Protein-22A was marginal. Proteins-315 and 460 have anti-dinitrophenyl activity, and their reactions with the corresponding BALB/c antibodies were inhibited by dinitrophenyl ligands. It appears that antibodies can be formed in BALB/c mice against unique “idiotypic” determinants in the ligand-binding sites of some BALB/c mycloma proteins.

Keywords: BALB, c/mice, plasmacytomas, anti-dinitrophenyl activity, idiotypic

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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