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. Author manuscript; available in PMC: 2014 Jan 20.
Published in final edited form as: NMR Biomed. 2012 Jan 27;25(9):1073–1087. doi: 10.1002/nbm.2772

Figure 3.

Figure 3

(A) Location of a 2.0 × 3.0 × 3.0-cm3 occipital lobe voxel in which glutathione (GSH) was measured. (B) Demonstration of in vivo human brain GSH detection by 1H MRS: spectra a and b, single-voxel subspectra acquired in 15 min with the editing pulse on and off and 290 (580 total) interleaved averages; spectrum c, difference between spectra a and b showing the edited brain GSH resonance; spectrum d, model fitting of spectrum c to obtain the GSH peak area; spectrum e, residual of the difference between spectra c and d. (C) Stacked plots of edited spectra obtained as in (B) from five randomly selected subjects showing clear and consistent detection of GSH. NAA, N-acetylaspartate; tCho, total choline; tCr, total creatine.