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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: J Immunol. 2013 Oct 23;191(11):5542–5550. doi: 10.4049/jimmunol.1301810

Figure VI. B7.H1 block increased phagocyte superoxide production and decreased parasite load.

Figure VI

(A) NBT assay performed on adherent PBMC from asymptomatic and symptomatic VL dogs after isotype, B7.H1, or IL-10 antibody treatment and stimulation with f-t L.i.. (B) L. infantum-specific quantitative RT-PCR performed on PBMC DNA. Data presented as number of genomic copies of L. infantum/106 PBMC from symptomatic dogs, after f-t L.i. stimulation (Li) compared to stimulation and addition of isotype, (left, Iso), anti-IL-10 (middle, IL-10), or anti-B7.H1antibody (right, B7.H1). (A) n=13 and (B) n=7. *p<0.05, **p<0.01, via one way ANOVA with Tukey’s post-test on averaged (A) or log-transformed (B) data.