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. Author manuscript; available in PMC: 2014 Jan 20.
Published in final edited form as: Chem Res Toxicol. 2012 Oct 18;25(12):2725–2736. doi: 10.1021/tx3003609

Figure 3.

Figure 3

QM release from X-ASA analogue, pBr-ASA, and pNO-ASA induces Nrf2 translocation in HepG2 cells. Immunofluorescence images of fluorescein Nrf2 staining and DAPI nuclear staining with overlapped images showing translocation of Nrf2 from cytoplasm to cell nucleus. HepG2 cells were treated: (A) for 4 h with DMSO, pNO-ASA (6.25 μM, 25 μM), 4'-bromoflavone (200 ng/mL), and pNO-ASA (25 μM) with LY29402; (B) DMSO control, or pBr-ASA (6.25 μM and 25 μM) after 4 or 18 h, respectively.