Table 1.
Genes up or downregulated ≥ 3-fold by C. burnetii after 14 days of growth in ACCM-1 as compared to growth in ACCM-2.
| CBU No. | Function | Gene | ACCM-2 signal | ACCM-1 signal | Fold change |
|---|---|---|---|---|---|
| CBU0926 | 3-hydroxyisobutyrate dehydrogenase | mmsB | 6,712 | 1,565 | −4.29 |
| CBU1847 | hypothetical protein | 4,056 | 1,053 | −3.85 | |
| CBU0956 | hypothetical protein | 10,987 | 2,860 | −3.84 | |
| CBU1078 | hypothetical protein | 3,136 | 896 | −3.50 | |
| CBU2021 | ATPase | 2,259 | 673 | −3.36 | |
| CBU0893 | acetyl-coA carboxylase carboxyl transferase subunit beta | accD | 3,708 | 1,150 | −3.22 |
| CBU0909 | sua5/YciO/YrdC/YwlC family protein | 4,330 | 1,365 | −3.17 | |
| CBU0480 | arginine repressor ArgR | argR | 7,601 | 2,463 | −3.09 |
| CBU1266 | lipoyl synthase | lipA | 1,128 | 370 | −3.05 |
| CBU0716 | thioredoxin reductase | 4,238 | 1,395 | −3.04 | |
| CBU0831 | asparagine synthetase | asnB-1 | 326 | 3.05 | |
| CBU1188 | seryl-tRNA synthetase | serS | 86 | 230 | 3.65 |
| CBU1629 | IcmL | icmL.1 | 400 | 1,200 | 3.63 |
| CBU1476 | hydrogen peroxide-inducible genes activator | oxyR | 1,688 | 5,122 | 3.03 |
| CBU1632 | IcmO | icmO | 575 | 1,763 | 3.06 |
| CBU1465 | hypothetical protein | 699 | 2,145 | 3.07 | |
| CBU1930a | hypothetical protein | 1,297 | 4,030 | 3.11 | |
| CBU1625 | hypothetical protein | icmC | 314 | 995 | 3.16 |
| CBU1469 | rod shape-determining protein | mreD | 504 | 1,597 | 3.17 |
| CBURNA046 | 23S rRNA | 13,591 | 43,479 | 3.20 | |
| CBU1471 | rod shape-determining protein MreB | mreB | 1,099 | 3,695 | 3.36 |
| CBU1348 | hypothetical protein | 128 | 460 | 3.49 | |
| CBU0745 | ribosome-associated factor Y | 1,081 | 3,916 | 3.62 | |
| CBU1474 | aspartyl/glutamyl-tRNA amidotransferase subunit A | gatA | 162 | 601 | 4.06 |
| CBU1412 | hypothetical protein | 278 | 1,043 | 3.76 | |
| CBU1626 | hypothetical protein | icmG | 395 | 1,514 | 3.84 |
| CBU0259 | hypothetical protein | 551 | 2,135 | 3.87 | |
| CBU1458a | hypothetical protein | 197 | 772 | 3.92 | |
| CBU1628 | IcmK | icmK | 535 | 2,172 | 4.06 |
| CBU0304 | endoribonuclease L-PSP | 1,297 | 5,441 | 4.19 | |
| CBU0311 | hypothetical protein | 399 | 1,923 | 4.82 | |
| CBU1479 | hypothetical protein | 140 | 674 | 4.83 | |
| CBU1470 | rod shape-determining protein MreC | mreC | 189 | 942 | 4.97 |
| CBU1472 | hypothetical protein | 1,249 | 5.93 | ||
| CBU0596a | hypothetical protein | 414 | 2,078 | 8.29 | |
| CBU1627 | IcmE | icmE | 155 | 799 | 5.16 |
| CBU1475 | aspartyl/glutamyl-tRNA amidotransferase subunit B | gatB | 164 | 896 | 5.46 |
| CBU1547 | thymidylate synthase | thyA | 227 | 1,299 | 5.72 |
| CBU1477 | peroxiredoxin | ahpC2 | 4,186 | 32,907 | 7.86 |
| CBU1931 | hypothetical protein | 142 | 1,258 | 8.84 | |
| CBU0083 | hypothetical protein | 316 | 2,825 | 8.95 | |
| CBU1473 | glutamyl/aspartyl-tRNA amidotransferase subunit C | gatC | 223 | 2,050 | 9.20 |
| CBU1478 | peroxiredoxin reductase | ahpD | 210 | 3,787 | 17.99 |