Skip to main content
. 2013 Dec 26;111(2):E283–E290. doi: 10.1073/pnas.1322057111

Fig. 4.

Fig. 4.

Large-scale gene analysis on response to E2 on C451A-ERα and ERα-AF20 mice. (A) Gene expression profiles were obtained by microarray analysis (Agilent SurePrint G3 Mouse GE, 8 × 60K) of uterine samples from C451A-ERα, ERα-AF20 mice or their littermate WT controls treated with E2 (8 µg/kg, 6 h) or vehicle (Veh), n = 3–4. The heat map represents the data obtained on all samples for the differentially expressed probes exhibiting interaction between genotype and treatment (BH adjusted P < 0.001). (B) The Venn diagram illustrates the overlaps between the genes significantly (P < 0.05) up- or down-regulated in the uterus following E2 treatment in ERα-AF20 and C451A-ERα mice. (C) The Venn diagram illustrates the overlaps between the genes significantly (BH adjusted P < 0.05) up- or down-regulated in the uterus following interaction between E2 treatment and genotypes, respectively, ERα-AF20 and C451A-ERα mice.