Table 4.
Multivariate analysis results for OS/NRM since enrollment
| OS | NRM | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | Category | p-value | HR | 95% HR CI | p-value | HR | 95% HR CI | ||
| Lower GI | Involved | 0.05 | 1.67 | 1.01 | 2.77 | 0.05 | 1.84 | 1.01 | 3.37 |
| Not involved | 1.00 | 1.00 | |||||||
| Bilirubin | Involved | 0.001 | 2.46 | 1.48 | 4.09 | 0.02 | 2.15 | 1.13 | 4.11 |
| Not involved | 1.00 | 1.00 | |||||||
| Site | FHCRC | 0.21 | 0.77 | 0.51 | 1.16 | 0.34 | 0.78 | 0.47 | 1.30 |
| Other sites | 1.00 | 1.00 | |||||||
| Case type | Incident | 0.37 | 0.80 | 0.49 | 1.31 | 0.62 | 0.86 | 0.48 | 1.56 |
| Prevalent | 1.00 | 1.00 | |||||||
| Time from HCT to enrollment | < 12 months | 0.34 | 1.28 | 0.77 | 2.11 | 0.49 | 0.81 | 0.44 | 1.48 |
| ≥ 12 months | 1.00 | 1.00 | |||||||
| Platelet | < 100K | 0.03 | 1.70 | 1.05 | 2.78 | 0.001 | 2.56 | 1.45 | 4.52 |
| ≥ 100K | 1.00 | 1.00 | |||||||
| KPS | < 80 | 0.005 | 1.87 | 1.21 | 2.89 | <0.001 | 2.77 | 1.59 | 4.83 |
| Missing | 0.18 | 1.46 | 0.84 | 2.56 | 0.01 | 2.48 | 1.25 | 4.93 | |
| ≥ 80 | 1.00 | 1.00 | |||||||
| Age at transplant, years | ≥ 50 | 0.72 | 1.08 | 0.71 | 1.66 | 0.78 | 0.93 | 0.55 | 1.57 |
| < 50 | 1.00 | 1.00 | |||||||
| Donor match | Matched unrelated | 0.75 | 1.08 | 0.68 | 1.70 | 0.34 | 1.32 | 0.75 | 2.33 |
| Mismatched | 0.57 | 1.17 | 0.68 | 2.01 | 0.56 | 1.22 | 0.63 | 2.36 | |
| Matched related | 1.00 | 1.00 | |||||||
| Donor/patient gender combination | Female donor male patients | 0.73 | 0.93 | 0.60 | 1.43 | 0.51 | 0.83 | 0.48 | 1.44 |
| Others | 1.00 | 1.00 | |||||||
| Conditioning type | Myeloablative | 0.42 | 0.84 | 0.55 | 1.28 | 0.14 | 0.68 | 0.41 | 1.14 |
| Non-myeloablative | 1.00 | 1.00 | |||||||
| Prior acute GVHD | Yes | 0.66 | 0.91 | 0.60 | 1.39 | 0.57 | 0.86 | 0.51 | 1.45 |
| No | 1.00 | 1.00 | |||||||