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Effect of compound 8c on β-catenin levels. See Supplemental Materials for experimental details.
A–C: Effects of compound 8c on free and total β-catenin protein levels in DLD-1 cells (A), SW480 cells (B) and HEK293T cells (C–E). C treated with 5 μM of the GSK3β antagonist SB216763. Compound 8c degrades β-catenin in a proteasome dependent fashion (D). Compound 8c degrades β-catenin in a βTrCP independent fashion (E).
