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. Author manuscript; available in PMC: 2014 Dec 23.
Published in final edited form as: Angew Chem Int Ed Engl. 2013 Nov 8;52(52):14181–14185. doi: 10.1002/anie.201307631

Table 1.

Initial Optimization of Hydroarylation Conditions[a]

graphic file with name nihms543194t1.jpg
entry X Y condition 4:5:6 Conv.[b]
1 Me Me A, 17 h 100:0:0 100
2 OMe H A, 17 h 71:29:0 53
3 OPiv H A, 17 h 0:0:100 61[c]
4 OMe H B, 2 h 0:100:0 100
5 OPiv H B, 12 h 0:22:78 100
[a]

Reactions conducted on 0.1 mmol scale. A: [RhCp*(MeCN)3](SbF6)2 (1 mol%), 1 equiv. tBuCO2H, 1,2-dichloroethane (0.2 M), 80 °C; B: [RhCp*Cl2]2 (2.5 mol%), CsOAc (2 equiv.), MeOH (0.2 M), rt

[b]

Conversion determined by 1H NMR.

[c]

Starting material hydrolysis also observed.