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GLI1 transcriptional activity and cytotoxicity.
| Compound | GLI1 transcriptional inhibition, IC50 (μM) | Cytotoxicity, IC50 (μM) | ||
| PANC1 | DU145 | C3H10T1/2 | ||
| physalin H (1) | 0.70 | 5.7 | 6.8 | >6.0 |
| physalin G (2) | 47.1 | – | >12.0 | – |
| physalin K (3) | – | – | – | – |
| isophysalin B (4) | 4.2 | 12.0 | >12.0 | >12.0 |
| physalin F (5)a | 0.66a | 2.7a | – | 15.0a |
| physalin B (6)a | 0.62a | 5.3a | – | 17.0a |
| 6 and 7 mixture (2:3) | 0.40 | 4.0 | 3.6 | >6.0 |
aData from [17].
