Figure 6. Rapid early T cell proliferation is accompanied by accumulation of CD11b+CD103-cells and can be inhibited by IL-1RA.
MLNs were dissected from RAG−/− and DKO mice 10 days after transfer with CD45RBhiCD4+ T cells. Mice were treated with either PBS or anakinra daily for the course of the experiment. (A) FACS plots pre-gated on live cells are shown. (B) FACS plots pre-gated on live CD11c+ cells are shown. Data shown is from one representative experiment with five mice per group. A repeat of this data is shown in Supplemental Figure 3.