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. 2013 Dec 1;101(2):326–334. doi: 10.1093/cvr/cvt269

Figure 5.

Figure 5

High-resolution optical mapping in isolated SK3T/T, SK3+/T, and WT mouse hearts. (A) Ventricular conduction velocity at a pacing cycle length of 150 ms in 1-month-old SK3T/T, SK3+/T, and WT mice. Conduction velocity was significantly slower in SK3T/T mice (CV 0.45 ± 0.04 vs. 0.60 ± 0.09 mm/ms, P = 0.001). (B) Representative example of ventricular activation maps on the anterior surface of the heart in a WT and SK3T/T mouse. Hearts were paced from the left ventricular apex at a cycle length of 150 ms, and epicardial activation was recorded as it spread from the apex to the base. (C) SK3T/T and SK3+/T mice do not display significant differences in APD80 when compared with WT mice. (D) SK3T/T display increased dispersion of the APD80 when compared with WT mice. SK3+/T mice on the other hand do not display differences in APD80 dispersion. APD measurements were made at a pacing cycle length of 150 ms. APD80, action potential duration at 80% repolarization.