Table 11.

Examples of 1,2,4-trioxolanes produced by the ozonolysis of alkenes.

Alkene 163	Ozonolysis conditions	1,2,4-Trioxolane 165	Yield, %	Reference
	Et2O, −70 °C		24	[270]
	Et2O, −70 °C		27	[270]
	hexane, −78 °C		78	[256]
	hexane, −78 °C		73	[256]
	hexane, −78 °C		77	[256]
	hexane, −78 °C		61	[256]
	isooctane/CCl4, −78 °C, 1 h		>82	[271]
	CH2Cl2, −78 °C		95	[272]
	CH2Cl2, −78 °C		90	[272]
	CH2Cl2, −78 °C		92	[272]
	CH2Cl2, −78 °C		93	[272]
	CH2Cl2, −78 °C		93	[272]
	CH2Cl2, −78 °C		94	[272]
	pentane, −78 °C		63	[272]
	freon-113, 15–20 °C, 2 h		The yield was not determined	[273–274]
	freon-113, 15–20 °C, 2 h		The yield was not determined	[273]
	CH2Cl2, −78 °C		96	[275]
	polymer-based, −78 °C, 8 h		23	[276]
	polymer-based, −78 °C, 3 h		38	[276]
	CH2Cl2, −70 °C		48	[277]
	without solvent, −133 to −43 °C		100	[278]
	1) CH2Cl2, −78 °C, 15 min. 2) Me2S, rt, 6 h		71	[279]
	hexane, −78 °C, 30 min		6	[280]
	CH2Cl2, −78 °C, 20 min		The yield was not determined	[281]
	CH2Cl2, −78 °C, 2 h		>97	[282]
	CDCl3, −65 °C		88	[283]
	CFCl3, −70 °C		100	[283]
	CH2Cl2, −78 °C, 1 h		85	[284]
	CH2Cl2, −78 °C, 1 h		70	[285]
	pentane, −78 °C		10-30	[148–152]
	Et2O/CH3OH, −78 °C		12	[254]
	CH2Cl2, −78 °C		92	[286]
	CH2Cl2, 0 °C		95	[287–288]
	H2O/CH2Cl2, 0 °C		72	[289]
	1) SiO2, −78 °C; 2) Me2S, MeOH		30	[290]