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Plasma concentration-time profile for Cu B in fasted male Beagle dogs after administration of Cu B in different formulations. Each point represents the mean ± standard deviation of five experiments.
Abbreviations: HPMC, hydroxypropyl methyl cellulose; SDC, sodium deoxycholate B; Cu B, Cucurbitacin B; PL, phospholipid; MMs, mixed micelles; TPGS, alpha-D-tocopherol polyethylene glycol 1000 succinate; h, hours.
