Table 3.
—Clinical Outcomes in the Second Multicenter Intrapleural Sepsis Trial
| Outcome | Tissue Plasminogen Activator | Placebo | P Value |
| Change in pleural opacification, % | − 17.2 ± 24.3 | − 17.2 ± 19.6 | NS |
| Death (3 mo) | 4 of 48 (8%) | 6 of 46 (13%) | NS |
| Surgical intervention (3 mo) | 3 of 48 (6%) | 6 of 51 (12%) | .025 |
| Hospital stay, d | 16.5 ± 22.8 | 24.8 ± 56.1 | .21 |
| Serious adverse events | 0 of 52 (0%) | 1 of 55 (2%) | NS |
Data are presented as mean ± SD unless otherwise indicated. NS = not significant.