Table 2.
Distribution of Genetic Alterations Detected by FISH in Patients With HGD and Mucosal Cancer
| Biomarker | HGD, N (%) (N = 104) | Mucosal cancer, N (%) (N = 22) | P valuea |
|---|---|---|---|
| Overall FISH positivity | 70 (68) | 16 (73) | .58 |
| P16 loss | 35 (32) | 6 (27) | .26 |
| P53 lossb | 28 (28) | 6 (30) | .85 |
| C-MYC (8q24) gain | 43 (46) | 12 (54) | .74 |
| HER2-NEU (17q) gain | 27 (27) | 6 (27) | .42 |
| 20q13 gain | 34 (33) | 11 (50) | .15 |
| Multiple gains | 36 (35) | 11 (50) | .19 |
| Multiple gains/any gains | 50 (51) | 12 (55) | .25 |
a
Obtained using the chi-square test or the Fischer exact test as appropriate.
b
Data available for 120 patients (100 patients with HGD and 20 with mucosal cancer).