Table 5. Clinical profiles of discovery, replication and validation cohorts in a 3-stage genome wide association study in Asian populations.
| Hong Kong Chinese | Shanghai Chinese | Japanese | Korean | Singapore Chinese (Illumina 610quad) | Singapore Chinese (Illumina1 Mduov3) | Singapore Malay | ||||||||||||
| Discovery cohort | Replication cohort | |||||||||||||||||
| T2D | Controls | T2D | Controls Adult | Controls adolescents | T2D | Controls | T2D | Controls | T2D | Controls | T2D | Controls | T2D | Controls | T2D | Controls | ||
| n | 99 | 101 | 1468 | 507 | 978 | 1892 | 1808 | 471 | 582 | 761 | 632 | 1082 | 1006 | 928 | 939 | 794 | 1240 | |
| Male | 40 | 37 | 592 | 234 | 457 | 988 | 749 | 262 | 204 | 354 | 286 | 402 | 217 | 602 | 599 | 405 | 645 | |
| Age (years) | 40.6±8.8 | 37.4±10.1 | 50±13.8 | 42.2±10.4 | 15.3±1.9 | 61.2±12.6 | 57.3±12.3 | 61.6±10.4 | 67.9±9.1 | 59.2±9.9 | 64.7±3.6 | - | 47.7±11.1 | - | 46.7±10.2 | 62.3±9.9 | 56.9±11.4 | |
| Age-at-diagnosis (year) | 31.8±7.7 | -- | 44.0±13.6 | -- | -- | 54.1±11.8 | - | 46.2±8.0 | - | 50.0±10.1 | - | 55.7±12.0 | - | 52.2±14.4 | - | - | - | |
| Body mass index (kg/m2) | 30.9±4.4 | 20.8±2 | 24.8±3.9 | 23.3±3.4 | 19.9±3.6 | 24.1±3.5 | 23.6±4.2 | 24.2±3.8 | 22.4±3.2 | 24.5±2.9 | 23.5±3.1 | 25.3±3.9 | 22.3±3.7 | 25.4±3.8 | 22.8±3.4 | 27.8±4.9 | 25.1±4.8 | |
| HbA1C (%) | 8.0±1.9 | -- | 8.0±2.0 | -- | -- | 9.2±2.4 | - | 7.9±1.6 | 5.0±0.4 | 8.1±1.6 | 5.3±0.3 | - | - | - | - | 8.1±1.8 | 5.6±0.3 | |
| Fasting plasma glucose (mmol/l) | 4.7±0.4 | -- | 4.9±0.4 | 4.7±0.3 | 13.0±5.2 | 5.0±0.5 | - | - | 8.6±2.6 | 5.0±0.5 | - | 4.7±0.45 | - | 4.7±0.5 | - | - | ||