Table 3.
Predictors of Adverse Outcome
| Baselines values | No events (n=83) |
Events (n=45) |
Hazard Ratio* (95% CI) |
p Value |
|---|---|---|---|---|
| Age (years) | 44.9 ± 10.8 | 37.9 ± 10.7 | 0.59 (0.43 – 0.80) | 0.001 |
| NYHA class III–IV (n/%) | 8 (10) | 11 (24) | 2.80 (1.40 – 5.58) | 0.003 |
| Loud P2 (n/%) | 27 (32) | 25 (55) | 3.92 (2.0 – 7.68) | <0.001 |
| Atrial fibrillation (n/%) | 13 (16) | 5 (11) | 0.66 (0.26 – 1.67) | 0.38 |
| LAV index (mL/m2) | 49.4 ± 15.5 | 56.9 ± 14.3 | 1.37 (1.04 – 1.79) | 0.010 |
| RVMPI | 0.29 ± 0.12 | 0.33 ± 0.11 | 1.41 (1.04 – 1.91) | 0.026 |
| Peak gradient (mmHg) | 15.2 ± 5.8 | 24.2 ± 9.2 | 2.19 (1.73 – 2.76) | <0.001 |
| Mean gradient (mmHg) | 8.2 ± 3.9 | 14.7 ± 6.4 | 2.09 (1.71 – 2.57) | <0.001 |
| MV area (cm2) | 1.4 ± 0.3 | 0.9 ± 0.2 | 0.13 (0.07 – 0.23) | <0.001 |
| SPAP (mmHg) | 36.9 ± 13.2 | 56.9 ± 22.6 | 1.93 (1.54 – 2.40) | <0.001 |
| Cn (mL/mmHg) | 5.1 ± 1.1 | 3.8 ± 1.2 | 0.30 (0.19 – 0.47) | <0.001 |
Data are expressed as the mean value ± SD or number (percentage) of patients.
*
hazard ratio per 1 SD increase
Cn = net atrioventricular compliance; LAV = left atrial volume; MV = mitral valve; P2 = pulmonic valve closure sound; RVMPI = Right ventricular myocardial performance index; SPAP = systolic pulmonary artery pressure