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. Author manuscript; available in PMC: 2014 Nov 14.
Published in final edited form as: J Med Chem. 2013 Nov 5;56(21):8626–8655. doi: 10.1021/jm401090a

Scheme 1.

Scheme 1

(a) LiBr, DME, 50 °C or i-PrOH, reflux. (b) chloroacetyl chloride, Et3N, CHCl3, room temp. (c) NaH, THF, room temp. (d) LiAlH4, THF, room temp. (e) 1,1′-carbonyldiimidazole, Et3N, CH2Cl2, room temp. (f) BBr3, CH2Cl2, room temp. (g) 2M NaOH, EtOH, reflux.