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SOICR inhibition by modified catechol analogs of 1.
| entry | compound | structure | IC50 (μM) ± SEM | repeats (n) | no. of cells |
|---|---|---|---|---|---|
| 1 | carvedilol 1 |
|
15.9 ± 2.5 | 6 | 375 |
| 2 | 6 |
|
11.2 ± 1.2 | 3 | 149 |
| 3 | 7 |
|
28.0 ± 0.6 | 3 | 191 |
| 4 | 8 |
|
16.8. ± 2.7 | 3 | 228 |
| 5 | 9 |
|
7.62 ± 0.44 | 3 | 159 |
| 6 | 10 |
|
15.1 ± 3.7 | 3 | 173 |
| 7 | 11 |
|
16.4 ± 4.2 | 3 | 235 |
| 8 | 12 |
|
11.6 ± 0.9 | 3 | 253 |
| 9 | 13 |
|
7.43 ± 0.65 | 3 | 202 |
| 10 | 14 |
|
8.52 ± 1.3 | 3 | 190 |
| 11 | 15 |
|
54.9 ± 5.7 | 3 | 255 |
| 12 | 16 |
|
35.2 ± 2.2 | 4 | 141 |
