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. Author manuscript; available in PMC: 2014 Nov 14.
Published in final edited form as: J Med Chem. 2013 Nov 5;56(21):8626–8655. doi: 10.1021/jm401090a

Table 3.

Effects of homologation and transposition of linker chain on SOICR inhibition.

entry compound structure IC50 (μM) ± SEM repeats (n) no. of cells
1 2 graphic file with name nihms535454t28.jpg 16.8 ± 3.3 4 206
2 32 graphic file with name nihms535454t29.jpg 14.6 ± 3.5 3 177
3 33 graphic file with name nihms535454t30.jpg 11.4 ± 0.8 3 245
4 34 graphic file with name nihms535454t31.jpg 13.5 ± 2.3 3 163
5 35 graphic file with name nihms535454t32.jpg 86.7 ± 53 3 204
6 36 graphic file with name nihms535454t33.jpg 20.0 ± 1.6 3 167
7 37 graphic file with name nihms535454t34.jpg 10.2 ± 0.5 3 168
8 38 graphic file with name nihms535454t35.jpg 9.51 ± 2.3 3 217
9 39 graphic file with name nihms535454t36.jpg 24.4 ± 3.1 4 365
10 40 graphic file with name nihms535454t37.jpg 26.7 ± 3.2 7 381