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SOICR inhibition by 3-carbazolyl analogs.
| entry | compound | structure | IC50 (μM) ± SEM | repeats (n) | no. of cells |
|---|---|---|---|---|---|
| 1 | 3 |
|
7.74 ± 1.1 | 7 | 367 |
| 2 | 41 |
|
6.20 ± 1.8 | 3 | 167 |
| 3 | 42 |
|
436 ± 330 | 3 | 150 |
| 4 | 43 |
|
9.72 ± 3.1 | 3 | 214 |
| 5 | 44 |
|
4.66 ± 0.13 | 3 | 164 |
| 6 | 45 |
|
15.9 ± 5.1 | 3 | 252 |
| 7 | 46 |
|
9.74 ± 2.8 | 3 | 185 |
| 8 | 47 |
|
6.26 ± 2.8 | 3 | 166 |
| 9 | 48 |
|
16.6 ± 4.3 | 3 | 235 |
