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. Author manuscript; available in PMC: 2014 Nov 14.
Published in final edited form as: J Med Chem. 2013 Nov 5;56(21):8626–8655. doi: 10.1021/jm401090a

Table 7.

Other modified carvedilol derivatives as SOICR inhibitors

entry compound structure IC50 (μM) ± SEM repeats (n) no. of cells
1 81 graphic file with name nihms535454t80.jpg >1000 3 193
2 82 graphic file with name nihms535454t81.jpg >1000 3 234
3 83 graphic file with name nihms535454t82.jpg 5.76 ± 1.3 4 299
4 84 graphic file with name nihms535454t83.jpg 15.8 ± 5.0 3 171
5 85 graphic file with name nihms535454t84.jpg 19.7 ± 9.0 3 188
6 86 graphic file with name nihms535454t85.jpg 8.61 ± 0.47 3 218
7 87 graphic file with name nihms535454t86.jpg >1000 3 153
8 88 graphic file with name nihms535454t87.jpg >1000 3 191
9 89 graphic file with name nihms535454t88.jpg 34.9 ± 3.7 3 148
10 90 graphic file with name nihms535454t89.jpg 62.7 ± 15 4 201
11 91 graphic file with name nihms535454t90.jpg 19.8 ± 1.7 3 187
12 92 graphic file with name nihms535454t91.jpg 94.5 ± 60 3 216
13 93 graphic file with name nihms535454t92.jpg 3.55 ± 0.30 3 158
14 94 graphic file with name nihms535454t93.jpg 3.63 ± 0.18 3 127