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. 2014 Jan 20;9(1):e85518. doi: 10.1371/journal.pone.0085518

Table 1. DNA recognition sequence of PAS heterodimers.

Heterodimer Name1 Sequence2
Sim/Tgo CME ACGTG
Trh/Tgo CME ACGTG
Dys/Tgo TCGTG
Dys/Tgo GCGTG 3
Dys/Tgo CME ACGTG 3
Sima/Tgo HRE RCGTG
Ss/Tgo XRE TNGCGTG
Per/Tim E box CACGTG
Clock/Bmal E box CACGTG

1 The names of the recognition sites are indicated: CNS midline enhancer (CME), hypoxia response element (HRE), xenobiotic response element (XRE) and the E box is the recognition site for bHLH proteins. Similar (Sima) is the fly hypoxia inducible factor-α, Spineless (Ss) functions in bristle, leg and antennal development and Period (Per), Timeless (Tim), Clock and Bmal function in circadian rhythms.

2 The CGTG core sequences shared by each recognition site are italicized.

3 The GCGTG and ACGTG sites are likely low affinity sites for Dys/Tgo [58].