Figure 1. Footpad swelling and mRNA expression of inflammatory cell markers in Cr-induced ICD and ACD mice.

(A) Footpad swelling at various time points. ICD, ACD, and control mice were analyzed at 1, 2, 3, 7, 10, and 14 days after challenge. (B) Footpad mRNA expression levels of IL-1β, HDC, CXCL10, CXCR3, CD14, and CD3 were assessed at the indicated days. Bars and error bars indicate mean ± SD. Statistical significance was tested by unpaired Student’s t-test (*p<0.05, **p<0.005).