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(A) Hepatic Cyp7a1 mRNA levels in mice 2 hrs after tail vein injection of vehicle (saline), FGF19 (10 µg/kg and 100 µg/kg body weight) *P<0.05, significant difference compared to vehicle-treated group. (B) Dose-dependency in activating ERK1/2 kinase in HepG2 cells by recombinant FGF19 for 2 hrs. (C) Time course in activating ERK1/2 kinase in HepG2 cells by 10 µg/ml FGF19.
