Table 5. SNPs genotypes frequencies of the 4 SNPs in the 2 subtype groups.
| SNP | Genotype | Controls (%) | Anencephaly (%) | Spina Bifida (%) |
| rs4586354 | TT | 164 (54.1) | 52 (53.1) | 29 (39.7) |
| CT+CC | 139 (45.9) | 46 (46.9) | 44 (60.3) | |
| OR(95%CI) | 1 | 1.04 (0.66,1.65) | 1.79 (1.06,3.01) | |
| P a | 0.85 | 0.027 | ||
| rs3783903 | AA | 165 (52.2) | 48 (47.5) | 26 (32.5) |
| AG+GG | 151 (47.8) | 53 (52.5) | 54 (67.5) | |
| OR(95%CI) | 1 | 1.21 (0.77,1.89) | 2.27 (1.35,3.81) | |
| P a | 0.41 | 0.002 | ||
| rs2236131 | GG | 181 (58) | 47 (47.5) | 31 (40.3) |
| AG+AA | 138 (42.3) | 52 (52.5) | 48 (58.5) | |
| OR(95%CI) | 1 | 1.45 (0.92,2.28) | 2.03 (1.23,3.36) | |
| P a | 0.11 | 0.008 | ||
| rs1740689 | AA | 139 (44.3) | 34 (27.3) | 21 (27.3) |
| AG+GG | 175 (55.8) | 63 (64.9) | 56 (72.3) | |
| OR(95%CI) | 1 | 1.47 (0.92,2.36) | 2.12 (1.22,3.67) | |
| P a | 0.11 | 0.007 |
Abbreviations: SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval.
a P values were calculated by x 2 test 2×2 contingency table for genotype distribution.