Table 6. SNPs genotypes frequencies of the 4 SNPs in the subtype of anencephaly.
| SNP | Genotype | Contol (%) | Total Anencephaly (%) | Anencephaly & SB*(%) | Only Anencephaly(%) |
| rs4586354 | TT | 164 (54.1) | 52 (53.1) | 33 (52.4) | 12 (52.2) |
| CT+CC | 139 (45.9) | 46 (46.9) | 30 (47.6) | 11 (74.8) | |
| OR(95%CI) | 1 | 1.04 (0.66,1.65) | 1.3 (0.75,2.2) | 1.02 (0.46,2.5) | |
| P a | 0.85 | 0.34 | 0.85 | ||
| rs3783903 | AA | 165 (52.2) | 48 (47.5) | 30 (47.6) | 11 (44) |
| AG+GG | 151 (47.8) | 53 (52.5) | 33 (52.4) | 14 (56) | |
| OR(95%CI) | 1 | 1.21 (0.77,1.89) | 1.2 (0.7,2.1) | 1.4 (0.6,3.5) | |
| P a | 0.41 | 0.5 | 0.4 | ||
| rs2236131 | GG | 181 (58) | 47 (47.5) | 33 (53.2) | 10 (41.6) |
| AG+AA | 138 (42.3) | 52 (52.5) | 29 (46.8) | 14 (58.4) | |
| OR(95%CI) | 1 | 1.45 (0.92,2.28) | 1.15 (0.67,1.9) | 1.8 (0.8,4.2) | |
| P a | 0.11 | 0.6 | 0.15 | ||
| rs1740689 | AA | 139 (44.3) | 34 (27.3) | 20 (32.8) | 8 (34.8) |
| AG+GG | 175 (55.8) | 63 (64.9) | 41 (67.2) | 15 (65.2) | |
| OR(95%CI) | 1 | 1.47 (0.92,2.36) | 1.63 (0.9,2.9) | 1.49 (0.6,3.6) | |
| P a | 0.11 | 0.1 | 0.37 |
*
Spina Bifida.
Abbreviations: SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval.
a
P values were calculated by x 2 test 2×2 contingency table for genotype distribution.