Table 7. SNPs genotypes frequencies of the 4 SNPs in the subtype of spina bifida.
| SNP | Genotype | Controls (%) | Spina Bifida (%) | Thoracic spina bifida with hydrocephalus (%) | Lumbar spina bifida with hydrocephalus (%) |
| rs4586354 | TT | 164 (54.1) | 29 (39.7) | 7 (30.4) | 13 (37) |
| CT+CC | 139 (45.9) | 44 (60.3) | 16 (69.6) | 22 (63) | |
| OR(95%CI) | 1 | 1.79 (1.06,3.01) | 2.6 (1.1,6.7) | 2 (0.97,4.1) | |
| P a | 0.027 | 0.03 | 0.042 | ||
| rs3783903 | AA | 165 (52.2) | 26 (32.5) | 10 (41.6) | 10 (28.6) |
| AG+GG | 151 (47.8) | 54 (67.5) | 14 (58.4) | 25 (71.4) | |
| OR(95%CI) | 1 | 2.27 (1.35,3.81) | 1.5 (0.6,3.5) | 2.7 (1.2,5.8) | |
| P a | 0.002 | 0.2 | 0.006 | ||
| rs2236131 | GG | 181 (58) | 31 (40.3) | 7 (31.8) | 12 (34.3) |
| AG+AA | 138 (42.3) | 48 (58.5) | 15 (68.2) | 23 (65.7) | |
| OR(95%CI) | 1 | 2.03 (1.23,3.36) | 2.8 (1.14,7.0) | 2.5 (1.26,5.2) | |
| P a | 0.008 | 0.027 | 0.009 | ||
| rs1740689 | AA | 139 (44.3) | 21 (27.3) | 6 (25) | 9 (25.6) |
| AG+GG | 175 (55.8) | 56 (72.3) | 18 (75) | 26 (74.4) | |
| OR(95%CI) | 1 | 2.12 (1.22,3.67) | 2.3 (0.9,6.1) | 2.3 (1.0,5.1) | |
| P a | 0.007 | 0.05 | 0.04 |
Abbreviations: SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval.
a
P values were calculated by x 2 test 2×2 contingency table for genotype distribution.