Figure 6. PKA inhibitors prevent the formation of long-range, inter-genic interactions between the PPARγ2 promoter and (A) the adiponectin promoter, (B) the leptin promoter, (C) the perilipin 1 promoter, (D) the perilipin 2/ADRP promoter.

The EF1α promoter (E) is shown as a control. Interaction frequencies were quantified as described in the legends for Figures 1–2. Results indicate the average of three independent experiments +/− standard deviation. Values for the 6 h samples differentiated in complete cocktail were compared to values for the samples differentiated for 6 h in complete cocktail containing the PKI or H89 inhibitors by one-tailed t-test. ***p<0.001.