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. Author manuscript; available in PMC: 2014 Jan 20.
Published in final edited form as: J Am Stat Assoc. 2008;103(481):259–270. doi: 10.1198/016214507000000356

Table 4.

Test sensitivity, specificity and probability of overdiagnosis by age at screen and thresholds of positive PSA test (in ng/ml).

Age at Screen PSA Thresholds (ng/ml)
2.0 2.5 3.0 3.5 4.0 4.5 5.0
Sensitivity
50 0.27 0.23 0.21 0.19 0.17 0.16 0.15
60 0.49 0.47 0.45 0.43 0.41 0.40 0.39
70 0.60 0.58 0.57 0.55 0.54 0.54 0.53
80 0.65 0.64 0.63 0.63 0.62 0.61 0.61

Specificity
50 0.76 0.80 0.82 0.84 0.86 0.87 0.88
60 0.58 0.60 0.62 0.64 0.65 0.67 0.68
70 0.50 0.52 0.53 0.54 0.55 0.56 0.57
80 0.47 0.48 0.49 0.50 0.51 0.51 0.52

Overdiagnosis
50 0.05 0.05 0.04 0.04 0.03 0.03 0.03
60 0.15 0.15 0.14 0.14 0.14 0.14 0.14
70 0.28 0.27 0.27 0.28 0.28 0.28 0.28
80 0.56 0.56 0.55 0.55 0.55 0.55 0.55