Table 4.
Test sensitivity, specificity and probability of overdiagnosis by age at screen and thresholds of positive PSA test (in ng/ml).
| Age at Screen | PSA Thresholds (ng/ml) | ||||||
|---|---|---|---|---|---|---|---|
| 2.0 | 2.5 | 3.0 | 3.5 | 4.0 | 4.5 | 5.0 | |
| Sensitivity | |||||||
| 50 | 0.27 | 0.23 | 0.21 | 0.19 | 0.17 | 0.16 | 0.15 |
| 60 | 0.49 | 0.47 | 0.45 | 0.43 | 0.41 | 0.40 | 0.39 |
| 70 | 0.60 | 0.58 | 0.57 | 0.55 | 0.54 | 0.54 | 0.53 |
| 80 | 0.65 | 0.64 | 0.63 | 0.63 | 0.62 | 0.61 | 0.61 |
|
| |||||||
| Specificity | |||||||
| 50 | 0.76 | 0.80 | 0.82 | 0.84 | 0.86 | 0.87 | 0.88 |
| 60 | 0.58 | 0.60 | 0.62 | 0.64 | 0.65 | 0.67 | 0.68 |
| 70 | 0.50 | 0.52 | 0.53 | 0.54 | 0.55 | 0.56 | 0.57 |
| 80 | 0.47 | 0.48 | 0.49 | 0.50 | 0.51 | 0.51 | 0.52 |
|
| |||||||
| Overdiagnosis | |||||||
| 50 | 0.05 | 0.05 | 0.04 | 0.04 | 0.03 | 0.03 | 0.03 |
| 60 | 0.15 | 0.15 | 0.14 | 0.14 | 0.14 | 0.14 | 0.14 |
| 70 | 0.28 | 0.27 | 0.27 | 0.28 | 0.28 | 0.28 | 0.28 |
| 80 | 0.56 | 0.56 | 0.55 | 0.55 | 0.55 | 0.55 | 0.55 |