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VPA inhibits the protein expression of HDAC1 and increases histone H3 acetylation. Nuclear proteins were extracted from tumors in the control and VPA-treated mice. Nuclear proteins of HDAC1 and acetylated histone H3 (Ac-H3) were immunoblotted using specific antibodies. Lamin B was used as a loading control. Lanes 1 and 2, control groups; lanes 3 and 4, VPA-treated groups; VPA, valproic acid; HDAC, histone deacetylase.
