Figure 3. VDZ does not affect suppressor activity of α₄⁺β₇⁺ Treg cells. (A) FoxP3⁺ Treg cells were examined for the expression of α₄ and β₇ by flow cytometry, demonstrating the FoxP3⁺ Treg population constitutes only approximately 13% of the CD4⁺ CD45RO β₇⁺ memory population. Results are representative of one of 3 experiments. (B) Suppressor activity of purified Treg cells was assessed after pre-incubation with vehicle, VDZ, natalizumab, FIB504, or isotype control, demonstrating a lack of effect of VDZ on suppressor cells. Results are from 3 donors.