Table 1. In vitro cytokine production (ng/mL)*.
| Time post treatment, h | Treatment | IFN-γ | IL-1β | IL-2 | IL-4 | IL-6 | IL-8 | IL-12 (p70) | IL-17 | TNF |
|---|---|---|---|---|---|---|---|---|---|---|
| 5.5 | PBS | 2.2 ± 3.5 | 0.2 ± 2.0 | 1.8 ± 2.0 | 1.0 ± 0.4 | 7.0 ± 1.8 | 30 ± 50 | 0.8 ± 0.3 | 6.9 ± 6.0 | 5.5 ± 6.0 |
| VDZ | 3.0 ± 5.0 | 0.2 ± 2.3 | 1.9 ± 2.3 | 1.4 ± 1.1 | 9.0 ± 8.2 | 29 ± 36 | 1.1 ± 0.9 | 7.4 ± 9.2 | 7.2 ± 9.7 | |
| LPS | 39 ± 13 | 118 ± 10 | 19 ± 10 | 9.2 ± 3.2 | 25517 ± 9614 | 5755 ± 1903 | 1.9 ± 1.3 | 56 ± 31 | 660 ± 211 | |
| 24 | PBS | 2.8 ± 4.4 | 0.2 ± 2.6 | 3.9 ± 2.6 | 1.0 ± 0.3 | 112 ± 191 | 422 ± 685.4 | 1.1 ± 0.8 | 27 ± 34 | 15 ± 14 |
| VDZ | 3.6 ± 6.2 | 0.2 ± 3.3 | 3.6 ± 3.3 | 0.9 ± 0.4 | 77 ± 122 | 126 ± 124 | 1.4 ± 1.4 | 31 ± 37 | 22 ± 25 | |
| LPS | 4345 ± 2963 | 3403 ± 30 | 50 ± 30 | 17 ± 1.8 | 49258 ± 9606 | 2292 ± 3632 | 4.0 ± 2.9 | 96 ± 83 | 1408 ± 517 |
LPS, lipopolysaccharide; IL, interleukin; PBS, phosphate-buffered saline; TNF, tumor necrosis factor; VDZ, vedolizumab; IFN, interferon. *n, 4