Figure 7. ADCC potencies have a nonlinear correlation to the percentage of afucosylation. Relative mean ADCC potencies were calculated from four independent assays using an engineered NK cell line and PBMCs from two different donors. Values were plotted against their corresponding fucose levels and normalized to WT. The data fits well into a nonlinear regression model demonstrating that the absence of only one core fucose is required to achieve high potencies similar to complete afucosylation. All replicates are in close agreement with one another.