Figure 1. Fc structure (A) indicating the locations of structural domains, two attached oligosaccharides colored cyan, and the position of Gly237 residues used to calculate the CH2-CH2 distance. For chain H, the CH2 domain is red and the CH3 domain is orange. For chain K, the CH2 domain is green and the CH3 domain is blue. The hinge, which was present in all glycoform variant simulations, has been left out of this representation for the sake of clarity. CH2 domain schematic (B) with β-strands labeled and residue indices for strands in Kabat numbering scheme. Two phenylalanine residues 241 and 243, important for CH2 domain stability, are located on β-strand A. The oligosaccharide attachment residue, Asn297, is located in loop C’E.