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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Cell Mol Bioeng. 2013 Dec;6(4):449–459. doi: 10.1007/s12195-013-0296-5

Figure 4. Shifting the optimum stiffness.

Figure 4

A) The Monte Carlo simulations produce a tunable optimum (cite BJ) which should be reproduced by the ODE solution. Increasing the numbers of motors and clutches from 25 to 3600 shifts the optimum stiffness (characterized by the minimum actin flow rate) from 0.4 pN/nm to 50 pN/nm. Monte Carlo actin flow was averaged over 106 events on each stiffness. B) The ODE solutions also produce an optimum stiffness, but the actin flow curves are shaped slightly differently than for the Monte Carlo output. Over the same change in motors and clutches, the optimum shifts from 1 pN/nm to 200 pN/nm, meaning that the use of the ODE solution may slightly over-predict the optimum stiffness. ODE solutions were obtained using r = 3.