Table 3.

Functional clustering of gene annotations using the DAVID resource reveals enrichment for genes involved in apoptosis in both treatments gene set (hgf-FNDF-LC₅₀ and SCFA-LC50, respectively)

Category	Term	Count	P value	FDR
Top cluster for the set of hgm-FNDF-LC 50 target genes
GOTERM_BP_FAT	Regulation of apoptosis	37	3.3E−27	5.5E−24
GOTERM_BP_FAT	Regulation of programmed cell death	37	4.6E−27	7.7E−24
GOTERM_BP_FAT	Regulation of cell death	37	5.3E−27	8.8E−24
GOTERM_BP_FAT	Apoptosis	33	4.0E−26	6.7E−23
GOTERM_BP_FAT	Programmed cell death	33	6.4E−26	1.1E−22
GOTERM_BP_FAT	Cell death	33	1.0E−23	1.7E−20
GOTERM_BP_FAT	Death	33	1.2E−23	2.1E−20
SP_PIR_KEYWORDS	Apoptosis	23	1.5E−21	1.8E−18
GOTERM_BP_FAT	Positive regulation of apoptosis	23	3.1E−17	5.2E−14
GOTERM_BP_FAT	Positive regulation of programmed cell death	23	3.6E−17	6.0E−14
GOTERM_BP_FAT	Positive regulation of cell death	23	4.0E−17	6.6E−14
GOTERM_BP_FAT	Induction of apoptosis	19	8.2E−15	1.4E−11
GOTERM_BP_FAT	Induction of programmed cell death	19	8.7E−15	1.4E−11
GOTERM_BP_FAT	Induction of apoptosis by intracellular signals	10	4.0E−12	6.6E−9
Top cluster for the set of SCFA-LC 50 target genes
GOTERM_BP_FAT	Regulation of apoptosis	37	3.3E−27	5.5E−24
GOTERM_BP_FAT	Regulation of programmed cell death	37	4.6E−27	7.7E−24
GOTERM_BP_FAT	Regulation of cell death	37	5.3E−27	8.8E−24
GOTERM_BP_FAT	Apoptosis	33	4.0E−26	6.7E−23
GOTERM_BP_FAT	Programmed cell death	33	6.4E−26	1.1E−22
GOTERM_BP_FAT	Cell death	33	1.0E−23	1.7E−20
GOTERM_BP_FAT	Death	33	1.2E−23	2.1E−20
SP_PIR_KEYWORDS	Apoptosis	23	1.5E−21	1.8E−18
GOTERM_BP_FAT	Positive regulation of apoptosis	23	3.1E−17	5.2E−14
GOTERM_BP_FAT	Positive regulation of programmed cell	23	3.6E−17	6.0E−14
GOTERM_BP_FAT	Positive regulation of cell death	23	4.E−17	6.6E−14
GOTERM_BP_FAT	Induction of apoptosis	19	8.2E−15	1.4E−11
GOTERM_BP_FAT	Induction of programmed cell death	19	8.7E−15	1.4E−11
GOTERM_BP_FAT	Induction of apoptosis by intracellular signals	10	4.0E−12	6.6E−9