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. 2014 Feb;95(2):205–213. doi: 10.1189/jlb.0313154

Figure 5. STAT3 inhibition suppressed Th17 responses.

Figure 5.

(A) Contour plots show a reduction in the CD4+, IL-17A+ population among allostimulated T cells (DC:CD4+ T cell ratio 1:30) in 5 day cocultures treated with S3I-201, compared with DMSO. (B, C) Effects of STAT3 inhibition on the percentage and absolute number of allostimulated CD4+, IL-17A+ T cells as triplicate means ± sd from 3 independent experiments. (D) Reduction in IL-17A protein concentration (triplicate means ± sd from 3 independent experiments) from the supernatants of 5 day allogeneic cocultures treated with S3I-201 or DMSO control. *P < 0.05, paired t test.